Endocrine Abstracts

Introduction: Neuroendocrine tumors (NET) represent a heterogeneous group of tumors with different locations, whose management is based on the pathology, immunohistochemical, genetic and molecular profile.Materials and method: We followed 8 patients with NET between 2014 and 2022 registered at the “C.I. Parhon” National Institute of Endocrinology, Bucharest, who benefited from peptide receptor radionuclide therapy (PRRT). Among them, 75% were m...

Introduction: The neuroendocrine tumor of the ampulla of Vater represent a very rare disease, corresponding up to 2% of the periampullary malignancies and less than 1% of gastrointestinal NET. Less than 130 patients have been reported until 2013. The biological and clinical behavior is very unpredictable especially if it’s associated with another tumor, like adenocarcinoma. We present a case of a fifty-one-years-old woman who complained of weight loss, jaundice, abdominal...

IntroductionThyrotropinoma is a rare pituitary tumor ( <2% of pituitary adenomas) arising from PIT1-lineage cells, which expresses and secrete TSH. In most cases, the etiology is unknown but rare cases have been described to arise in context of MEN 1 syndrome. Diagnosis is often delayed by confusion with primary hyperthyroidism, which determine the tumor to be already large and invasive at the time of diagnosis. GH and prolactin cosecretion is an increas...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by germline mutations of MEN1 gene, without genotype–phenotype correlation. It is defined as the occurrence of two or more primary neuroendocrine tumors (parathyroid, enteropancreatic, pituitary), or the occurrence of one of the MEN1-associated tumors in family members of a patient with a clinical diagnosis of MEN1. Multiple parathyroid tumors with hyperparathyroidism are the most common m...